There are a number of things you need to watch out for when connecting to APIs secured with Azure AD from SharePoint Framework solutions.
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If you host your APIs on Azure, secure them with Azure AD and want to use them in the SharePoint Framework, you need to setup CORS correctly.
Building daemon applications that communicate with SharePoint Online? Here is how you can get an Azure AD app-only access token in .NET Core.
At the recent TechDays NL 2016 I had the pleasure of presenting three sessions about developing on the Office platform. Here are the slides I used.